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. Author manuscript; available in PMC: 2021 Aug 10.
Published in final edited form as: J Control Release. 2020 Jun 10;324:679–694. doi: 10.1016/j.jconrel.2020.06.006

Figure 3.

Figure 3.

Confocal microscopy is used to assess the self-assembling nature of PLGA-PEG-PLGA block copolymer in fabricating EXO-MS by fluorescently labelling copolymer segments (A, scale = 50 μm). PLGA (red, imaged with 561 nm laser channel) forms a uniform sphere, with pockets of interior PEG (blue, imaged with 405 nm laser channel) forming smaller spheres within the PLGA; fluorescently labelled exosomes (green, imaged with 488 nm laser channel) colocalize with PEG (blue) which facilitates encapsulation by self-assembly by forming hydrophilic pockets within the polymer MS. Compared to triblock PLGA-PEG-PLGA, diblock H3C-PEG-PLGA results in less regularly shaped polymeric spheres. High magnification (B, left, scale = 20 μm) and low magnification (B, right, scale = 200 μm).