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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Anesthesiology. 2020 Sep;133(3):595–610. doi: 10.1097/ALN.0000000000003452

Figure 4. Effects of Nuak1 inhibitor HTH-01–015 on Tau and oligomer Tau amounts in neonatal mice from both sexes.

Figure 4.

(a) Experimental design: Mice were treated with baseline or sevoflurane anesthesia with vehicle (DMSO) or HTH-01–015. (b) ATP concentration in cortex of neonatal mice from both sexes and female reference mice in baseline and sevoflurane anesthesia groups (n=6 mice/group). (c) Amounts of Tau and oligomer Tau (T22) in the cortex of neonatal mice from both sexes and female reference group mice. (d) Summary of Tau (n=6 mice/group). (e) Summary of Tau 22 (n=6 mice/group). (f) ELISA of total Tau in cortex of neonatal mice from both sexes and female reference group mice (n=6 mice/group). Data are presented as mean ± standard deviation (SD). All data are quantified and expressed as arbitrary units or real number compared to baseline group (non-anesthetized mice). PS, phosphorylated serine; PT, phosphorylated threonine; ELISA, enzyme-linked immunosorbent assay; DMSO, dimethylsulfoxide. One-way ANOVA: (b), (d), (e) and (f). *P<0.05; #P<0.05.