Table 3.
Univariable and multivariable 6-month landmark analyses of factors associated with OS, PFS, and NRM.
| Univariable Analysis |
Multivariable Analysis |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OS (n=121) | PFS (n=110) | NRM (n=110) | OS (n=121) | PFS (n=110) | NRM (n=110) | |||||||
| HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | |
| Sarcopenia | 0.03 | 0.01 | 0.19 | 0.03 | 0.02 | - | - | |||||
| No | Ref. | Ref. | Ref. | Ref. | Ref. | |||||||
| Yes | 3.12 (1.10–8.86) | 4.57 (1.40–15.0) | 2.27 (0.66–7.78) | 3.12 (1.10–8.89) | 4.20 (1.27–13.9) | |||||||
| HCT-CI | 0.004 | 0.006 | 0.002 | 0.004 | 0.009 | 0.002 | ||||||
| 0–2 | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | ||||||
| ≥3 | 2.93 (1.42–6.05) | 2.68 (1.33–5.40) | 3.04 (1.22–7.55) | 2.94 (1.42–6.07) | 2.65 (1.28–5.49) | 3.04 (1.22–7.55) | ||||||
| aGVHD | 0.14 | 0.03 | 0.37 | - | - | 0.11 | - | - | ||||
| Grade 0–1 | Ref. | Ref. | Ref. | Ref. | ||||||||
| Grade 2–4 | 1.69 (0.84–3.37) | 2.13 (1.07–4.24) | 1.50 (0.62–3.63) | 1.76 (0.88–3.52) | ||||||||
| Age (per 10 years) | 1.04 (0.99–1.09) | 0.17 | 1.04 (0.99–1.09) | 0.10 | 1.03 (0.97–1.10) | 0.36 | - | - | 1.01 (0.96–1.06) | 0.75 | - | - |
Abbreviations: OS, Overall survival; PFS, Progression free survival; NRM, Non-relapse mortality; HR, Hazard ratio; CI, Confidence interval; HCT-CI, Hematopoietic cell transplantation-comorbidity index; Ref., Reference; aGVHD, Acute graft-versus-host disease.