Figure 1.

Body weight changes of BALB/c mice over one-year post IV administration of various SNPs at indicated doses. The increasing body weight rate of injected female and male BALB/c mice was the same as relevant sex of saline injected control groups. Inset: Body weight changes of dead mice during one year. Four out of 80 animals died during the one-year study two of which were saline injected mice (female and male) and two were females that received large Stöber silica nanoparticles (SNPs500).