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. Author manuscript; available in PMC: 2021 Aug 13.
Published in final edited form as: J Med Chem. 2020 Jul 16;63(15):8419–8431. doi: 10.1021/acs.jmedchem.0c00770

Figure 3.

Figure 3.

Deconstruction strategy and inhibition evaluation of the compounds. The IC50 value of 8 was determined by MALDI-MS methylation inhibition assay while 9 was determined by the SAHH-coupling assay.