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. Author manuscript; available in PMC: 2021 Aug 13.
Published in final edited form as: J Med Chem. 2020 Jul 16;63(15):8419–8431. doi: 10.1021/acs.jmedchem.0c00770

Figure 8.

Figure 8.

Inhibition Mechanism Studies for compounds 1-3. (A-C) IC50 curves of 1-3 at varying concentrations of peptide with fixed concentration of SAM; (D-F) IC50 curves of 1 - 3 at varying concentrations of SAM with fixed concentration of peptide. The pre-incubation time for the assay was 120 min, and all the experiment were run in duplicates (n = 2).