TABLE 1.

Parameters calculated from agonist and antagonist concentration–response curves for AmGABA receptors obtained in Xenopus oocytes

	GABA (n = 16)		Muscimol (n = 11)		Dieldrin (n = 7)		Fipronil (n = 11)		Ivermectin (n = 9)		Picrotoxin (n = 12)
	EC50 (μM)	n H	EC50 (μM)	n H	IC50 (nM)	n H	IC50 (nM)	n H	IC50 (nM)	n H	IC50 (nM)	n H
AmRDL	24.29 ± 0.02	2.01	19.74 ± 0.01	2.11	6.88 ± 0.07	1.58	12.99 ± 0.04	0.46	181.18 ± 0.11	1.17	131.6 ± 0.08	0.88
AmRDL/LCCH3	29.47 ± 0.01	2.17	23.88 ± 0.03	2.04	8.59 ± 0.04	1.82	4.27 ± 0.04*	0.55	99.29 ± 0.09 #	0.93*	26.05 ± 0.11*	0.67
AmRDL/GRD	27.59 ± 0.01	2.09	19.44 ± 0.00	2.15	8.91 ± 0.03	1.43	11.85 ± 0.05	0.43	64.62 ± 0.05 #	0.91*	219.5 ± 0.10*	1.01
AmGRD/LCCH3	5.34 ± 0.01*	1.18*	2.28 ± 0.01*	1.36*	4.18 ± 0.04*	1.77	18.61 ± 0.05	0.44	126.84 ± 0.10	0.88*	568.4 ± 0.06*	0.89

Note: GRD/LCCH3 receptors display a higher potency for GABA and muscimol, and a n _H lower than that observed with RDL homomers and heteromers suggesting a unique GABA binding site.

^* P < .05, significantly different from corresponding value for AmRDL homomers; Holm–Sidak method.

^# P < .05, significantly different from corresponding value for AmRDL homomers; Dunn's method.