FIGURE 8.

Effect of Δ⁹‐THCA‐A on circulating profile of immunomodulatory cytokines in a mouse model of collagen‐induced arthritis. A panel of cytokines was assayed in control and CIA mice by multiplex immunoassay at the end of the period of treatment. The cytokines assayed were (a) IL‐6; (b) TNF‐α; (c) IFN‐γ; (d) IL‐10; and (e) IL‐17. In addition, (f) determination of total Ig antibodies against Type II Collagen by elisa are shown for the five experimental groups. Values correspond to means ± SEM of nine mice per group. ^* P < 0.05, significantly different as indicated