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. 2020 Aug 14;10:13831. doi: 10.1038/s41598-020-70764-x

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Drug interaction between 116-9e (DNAJA1 inhibitor) and selected hits. LNCaP cells were treated with different concentrations of cabozantinib (A), clofarabine (B), vinblastine (C), idarubicin (D), omacetaxine (E) and sorafenib (F) with or without 116-9e for 72 h in RPMI-1640 medium containing 10% FBS. Each point is the mean ± SD for three independent experiments. Growth inhibition was determined using Cell Titer-Glo assay. Combination Index (CI, measure of drug synergy) was determined using Chou-Talalay method via Compusyn software. CI values are as follows: < 0.1 (very strongly synergistic), 0.1–0.3 (strongly synergistic), < 0.9 (synergistic), 0.9–1.1 (additive), 1.1–3.3 (antagonistic), 3.3–10 (strongly antagonistic), > 10 (very strongly antagonistic).