Fig. 3.

The hub molecules were identified with protein–protein interaction (PPI)-based molecular complex detection (MCODE) using 130 overlapped molecules (phosphoproteins; invasive DEPs) in NFPAs. a The protein–protein interactions (PPIs) with combined scores greater than 0.4 were selected to construct PPI network. b The entire PPI network was analyzed using molecular complex detection (MCODE), and one module was obtained with module score = 5.778. The different colored nodes represent different query proteins and first shell of interactors. The white nodes represent second shell of interactors. The empty nodes represent the proteins with unknown 3D structure. The filled nodes represent the proteins with known or predicted 3D structure