Table 3.
Functional characteristics of 1035 phosphoproteins in NFPAs, clustered with GO and KEGG pathway enrichments. Count means the number of genes enriched in each item
| Category | Function characteristics | Count | % | Fold enrichment | P value | Gene name of phosphoprotein |
|---|---|---|---|---|---|---|
| Annotation cluster 1 | ||||||
| GOTERM_CC_DIRECT | GO:0005913~cell–cell adherens junction | 71 | 7.57 | 4.44 | 2.23E-26 | CAST, HSP90AB1, LIMA1, TLN1, SEPT2, ZC3HAV1, VAPB, H1FX, EIF2A, EPS15L1, VCL, LARP1, BZW1, CTTN, PAK2, SLK, PCBP1, ARHGAP1, FAM129B, AHNAK, GOLGA3, DAB2IP, BSG, LYN, PKN2, KTN1, MYH9, CTNNA1, FLNA, CTNNA2, RSL1D1, EIF4G1, EIF4G2, EPB41L1, PGM5, DHX29, SERBP1, USO1, EEF1D, CD226, DBN1, ADD1, ALDOA, HDLBP, YWHAZ, USP8, PPME1, CALD1, ASAP1, CTNND1, KLC2, ESYT2, TAGLN2, SCRIB, CHMP2B, MACF1, NDRG1, PLEC, ZC3H15, YWHAE, MPRIP, TNKS1BP1, EPS15, TJP1, LASP1, TMOD3, SPTBN1, NOP56, TMPO, TJP2, SPTAN1 |
| GOTERM_MF_DIRECT | GO:0098641~cadherin binding involved in cell–cell adhesion | 68 | 7.25 | 4.49 | 9.96E-26 | CAST, HSP90AB1, LIMA1, TLN1, SEPT2, ZC3HAV1, VAPB, H1FX, EIF2A, EPS15L1, VCL, LARP1, BZW1, CTTN, PAK2, SLK, PCBP1, ARHGAP1, FAM129B, AHNAK, GOLGA3, DAB2IP, BSG, PKN2, KTN1, MYH9, CTNNA1, FLNA, CTNNA2, RSL1D1, EIF4G1, EIF4G2, EPB41L1, DHX29, SERBP1, USO1, EEF1D, DBN1, ADD1, ALDOA, YWHAZ, HDLBP, USP8, PPME1, CALD1, ASAP1, CTNND1, KLC2, ESYT2, TAGLN2, SCRIB, CHMP2B, MACF1, NDRG1, PLEC, ZC3H15, YWHAE, MPRIP, EPS15, TNKS1BP1, TJP1, LASP1, TMOD3, SPTBN1, NOP56, TMPO, TJP2, SPTAN1 |
| GOTERM_BP_DIRECT | GO:0098609~cell–cell adhesion | 60 | 6.40 | 4.33 | 6.80E-22 | CAST, HSP90AB1, LIMA1, SEPT2, ZC3HAV1, VAPB, H1FX, EPS15L1, EIF2A, LARP1, BZW1, CTTN, SLK, PAK2, PCBP1, ARHGAP1, FAM129B, AHNAK, GOLGA3, DAB2IP, BSG, PKN2, KTN1, RSL1D1, EIF4G1, EIF4G2, EPB41L1, DHX29, SERBP1, USO1, EEF1D, DBN1, ADD1, ALDOA, YWHAZ, HDLBP, USP8, PPME1, CALD1, ASAP1, KLC2, TAGLN2, ESYT2, CHMP2B, MACF1, NDRG1, PLEC, ZC3H15, YWHAE, MPRIP, EPS15, TNKS1BP1, TJP1, LASP1, TMOD3, SPTBN1, TMPO, NOP56, TJP2, SPTAN1 |
| Annotation cluster 2 | ||||||
| KEGG_PATHWAY | hsa04130:SNARE interactions in vesicular transport | 8 | 0.85 | 4.47 | 1.62E-03 | STX1A, STX4, SEC22B, VAMP4, BET1L, SNAP23, VAMP2, STX1B |
| GOTERM_MF_DIRECT | GO:0005484~SNAP receptor activity | 8 | 0.85 | 3.93 | 3.66E-03 | STX1A, STX4, SEC22B, VAMP4, BET1L, SNAP23, VAMP2, STX1B |
| GOTERM_CC_DIRECT | GO:0031201~SNARE complex | 9 | 0.96 | 3.43 | 4.28E-03 | STX1A, STX4, SEC22B, VAMP4, BET1L, SNAP23, VAMP2, STX1B, STXBP5L |
| Annotation cluster 3 | ||||||
| GOTERM_BP_DIRECT | GO:0033523~histone H2B ubiquitination | 4 | 0.43 | 9.79 | 6.11E-03 | LEO1, PAF1, RNF20, CTR9 |
| GOTERM_BP_DIRECT | GO:0010390~histone monoubiquitination | 4 | 0.43 | 7.12 | 1.61E-02 | LEO1, PAF1, RNF20, CTR9 |
| GOTERM_BP_DIRECT | GO:0001711~endodermal cell fate commitment | 3 | 0.32 | 9.79 | 3.40E-02 | LEO1, PAF1, CTR9 |
| GOTERM_CC_DIRECT | GO:0016593~Cdc73/Paf1 complex | 3 | 0.32 | 8.65 | 4.35E-02 | LEO1, PAF1, CTR9 |
| Annotation cluster 4 | ||||||
| GOTERM_CC_DIRECT | GO:0016460~myosin II complex | 4 | 0.43 | 11.53 | 3.64E-03 | MYL12B, MYH14, MYH9, MYH10 |
| GOTERM_CC_DIRECT | GO:0097513~myosin II filament | 3 | 0.32 | 20.18 | 7.10E-03 | MYH14, MYH9, MYH10 |
| Annotation cluster 5 | ||||||
| GOTERM_MF_DIRECT | GO:0005344~oxygen transporter activity | 5 | 0.53 | 6.84 | 4.84E-03 | IPCEF1, HBA2, HBA1, HBB, HBD |
| GOTERM_BP_DIRECT | GO:0015671~oxygen transport | 5 | 0.53 | 6.52 | 5.85E-03 | IPCEF1, HBA2, HBA1, HBB, HBD |
| GOTERM_MF_DIRECT | GO:0031720~haptoglobin binding | 3 | 0.32 | 19.14 | 7.88E-03 | HBA2, HBA1, HBB |
| GOTERM_CC_DIRECT | GO:0031838~haptoglobin–hemoglobin complex | 3 | 0.32 | 15.14 | 1.37E-02 | HBA2, HBA1, HBB |
| GOTERM_CC_DIRECT | GO:0005833~hemoglobin complex | 4 | 0.43 | 6.73 | 1.90E-02 | HBA2, HBA1, HBB, HBD |
| Annotation cluster 6 | ||||||
| GOTERM_CC_DIRECT | GO:0005952~cAMP-dependent protein kinase complex | 4 | 0.43 | 11.53 | 3.64E-03 | PRKAR2B, PRKAR2A, PRKAR1A, PRKACB |
| GOTERM_MF_DIRECT | GO:0034236~protein kinase A catalytic subunit binding | 4 | 0.43 | 5.47 | 3.35E-02 | PRKAR2B, PRKAR2A, GSK3A, PRKAR1A |
| GOTERM_MF_DIRECT | GO:0008603~cAMP-dependent protein kinase regulator activity | 3 | 0.32 | 8.20 | 4.80E-02 | PRKAR2B, PRKAR2A, PRKAR1A |
| Annotation cluster 7 | ||||||
| GOTERM_BP_DIRECT | GO:1904903~ESCRT III complex disassembly | 4 | 0.43 | 7.83 | 1.21E-02 | CHMP2A, VPS4B, VPS4A, CHMP2B |
| GOTERM_BP_DIRECT | GO:1902188~positive regulation of viral release from host cell | 4 | 0.43 | 7.12 | 1.61E-02 | CHMP2A, VPS4B, VPS4A, CHMP2B |
| Annotation cluster 8 | ||||||
| GOTERM_CC_DIRECT | GO:0016282~eukaryotic 43S preinitiation complex | 4 | 0.43 | 5.38 | 3.52E-02 | EIF3CL, EIF3B, EIF3G, DHX29 |