Table 6.
Statistically significant KEGG signaling pathways identified from 130 overlapped molecules between phosphoproteins and invasive DEGs in NFPAs. Count means the number of genes enriched in each pathway
| Category | Pathway name | Count | % | Fold enrichment | P value | Benjamini | Gene name of overlapped molecule |
|---|---|---|---|---|---|---|---|
| KEGG_PATHWAY | hsa04611:Platelet activation | 10 | 7.94 | 10.58 | 2.53E-07 | 3.61E-05 | AKT1, TLN2, STIM1, GNAS, SNAP23, PRKG1, ARHGEF12, ITPR1, ITPR2, ITGA2B |
| KEGG_PATHWAY | hsa04270:Vascular smooth muscle contraction | 8 | 6.35 | 9.41 | 1.64E-05 | 1.17E-03 | CALD1, GNAS, PRKG1, ARHGEF12, PRKCD, ITPR1, ARHGEF11, ITPR2 |
| KEGG_PATHWAY | hsa04915:Estrogen signaling pathway | 6 | 4.76 | 8.34 | 6.44E-04 | 3.02E-02 | AKT1, FKBP5, GNAS, PRKCD, ITPR1, ITPR2 |
| KEGG_PATHWAY | hsa04666:Fc gamma R-mediated phagocytosis | 5 | 3.97 | 8.19 | 2.89E-03 | 9.82E-02 | AKT1, ASAP2, ASAP1, MARCKS, PRKCD |
| KEGG_PATHWAY | hsa04922:Glucagon signaling pathway | 5 | 3.97 | 6.95 | 5.21E-03 | 1.39E-01 | AKT1, ACACA, GNAS, ITPR1, ITPR2 |
| KEGG_PATHWAY | hsa04730:Long-term depression | 4 | 3.17 | 9.17 | 8.74E-03 | 1.89E-01 | GNAS, PRKG1, ITPR1, ITPR2 |
| KEGG_PATHWAY | hsa05205:Proteoglycans in cancer | 6 | 4.76 | 4.13 | 1.34E-02 | 2.40E-01 | AKT1, ANK1, ARHGEF12, ITPR1, PXN, ITPR2 |
| KEGG_PATHWAY | hsa04910:Insulin signaling pathway | 5 | 3.97 | 4.98 | 1.64E-02 | 2.55E-01 | AKT1, PRKAR2B, SLC2A4, TSC2, ACACA |
| KEGG_PATHWAY | hsa04970:Salivary secretion | 4 | 3.17 | 6.40 | 2.30E-02 | 3.09E-01 | GNAS, PRKG1, ITPR1, ITPR2 |
| KEGG_PATHWAY | hsa04540:Gap junction | 4 | 3.17 | 6.25 | 2.44E-02 | 2.98E-01 | GNAS, PRKG1, ITPR1, ITPR2 |
| KEGG_PATHWAY | hsa04022:cGMP-PKG signaling pathway | 5 | 3.97 | 4.35 | 2.55E-02 | 2.85E-01 | AKT1, SLC8A2, PRKG1, ITPR1, ITPR2 |
| KEGG_PATHWAY | hsa04912:GnRH signaling pathway | 4 | 3.17 | 6.05 | 2.66E-02 | 2.75E-01 | GNAS, PRKCD, ITPR1, ITPR2 |
| KEGG_PATHWAY | hsa04750:Inflammatory mediator regulation of TRP channels | 4 | 3.17 | 5.62 | 3.22E-02 | 3.02E-01 | GNAS, PRKCD, ITPR1, ITPR2 |
| KEGG_PATHWAY | hsa04020:Calcium signaling pathway | 5 | 3.97 | 3.84 | 3.79E-02 | 3.26E-01 | SLC8A2, STIM1, GNAS, ITPR1, ITPR2 |