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. 2020 Aug 15;17:242. doi: 10.1186/s12974-020-01911-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Bar graph showing results from the cylinder test for paw bias at three different time points: baseline (before surgery), 1-month post-surgery, and 2-month post-surgery. Heterozygous nude rats injected with AAV9-αsyn slowly developed a paw bias with more right paw touches that became significant at 2 months post-surgery when compared to GFP-injected controls (Two-way ANOVA, mixed-effects analysis p < 0.0001; F (1.96, 79.15) = 13.31 post hoc analysis: Tukey’s multiple comparison test, p = 0.0003), whereas T cell deficient nude rats injected with AAV9-αsyn did not develop a significant paw bias at any time point tested. Ten animals per group were used (nude rats—GFP, α-synuclein; heterozygous nude rats—GFP, α-synuclein). The bars in the graph represent mean±standard error of the mean