Table 2.
Markers of ovarian reserve (serum hormones, ovarian volume, and antral follicular count) at baseline and after 6 months of therapy in the cyclophosphamide (CYC) and mycophenolate mofetil (MMF) groups
| Parameter* | CYC (n = 25) | MMF (n = 25) | Between-group p value (baseline) | Between-group p value (6 months) | ||||
|---|---|---|---|---|---|---|---|---|
| Baseline | 6 months | p value | Baseline | 6 months | p value | |||
| LH (IU/ml) | 5.8 ± 3.6 | 17.6 ± 38.4 | 0.13 | 9.4 ± 7.7 | 8.3 ± 5.6 | 0.55 | 0.065 | 0.55 |
| FSH (IU/ml) | 5.2 ± 3.4 | 25.1 ± 46.0 | 0.03 | 4.8 ± 1.8 | 6.1 ± 3.1 | 0.07 | 0.938 | 0.36 |
| E2 (pg/ml) | 80.2 ± 57.6 | 56.1 ± 52.3 | 0.13 | 89.6 ± 67.3 | 113.0 ± 73.3 | 0.25 | 0.749 | < 0.001 |
| AMH (ng/ml) | 5.7 ± 6.7 | 1.2 ± 1.7 | 0.002 | 6.3 ± 3.9 | 5.8 ± 5.6 | 0.71 | 0.061 | < 0.001 |
| Inhibin B (pg/ml) | 56.1 ± 21.9 | 16.5 ± 18.0 | < 0.001 | 53.1 ± 24.7 | 82.9 ± 37.7 | 0.002 | 0.547 | < 0.001 |
| Ovarian volume (cm3) | 29.3 ± 15.8 | 17.9 ± 13.7 | 0.005 | 25.7 ± 20.4 | 26.1 ± 11.1 | 0.92 | 0.49 | 0.02 |
| Antral follicular count | 6.4 ± 2.4 | 5.5 ± 4.2 | 0.32 | 6.7 ± 2.5 | 8.0 ± 3.0 | 0.07 | 0.74 | 0.02 |
LH luteinizing hormone, FSH follicle-stimulating hormone, E2 estradiol, AMH anti-Mullerian hormone, CYC cyclophosphamide, MMF mycophenolate mofetil *Reported as mean ± SD