Table 3.
Model results for the associations between sleep duration and each abnormal serum lipid level
| Sleep duration (h) | Event, n(%) | Model 1 | P value | Model 2 | P value | Model 3 | P value | Sensitivity analysisa |
|---|---|---|---|---|---|---|---|---|
| HR(95% CI) | HR(95% CI) | HR(95% CI) | HR(95% CI) | |||||
| TC | ||||||||
| ≤ 5 | 902(43.34) | 0.95(0.88–1.02) | 0.170 | 0.95(0.88–1.02) | 0.174 | 0.96(0.89–1.04) | 0.331 | 0.99(0.90–1.10) |
| 6.0 | 2397(44.50) | 1.00(0.94–1.06) | 0.945 | 1.00(0.94–1.05) | 0.893 | 1.00(0.95–1.06) | 0.901 | 1.06(0.98–1.14) |
| 7.0 | 2520(44.81) | reference | reference | reference | reference | |||
| 8.0 | 8741(42.49) | 0.93(0.89–0.97) | 0.001 | 0.99(0.94–1.03) | 0.527 | 0.99(0.94–1.04) | 0.647 | 1.06(0.99–1.13) |
| ≥ 9 | 237(39.83) | 0.92(0.80–1.05) | 0.216 | 0.92(0.81–1.05) | 0.230 | 0.93(0.81–1.06) | 0.278 | 0.98(0.83–1.16) |
| TG | ||||||||
| ≤ 5 | 555(26.67) | 0.97(0.88–1.06) | 0.495 | 0.96(0.87–1.05) | 0.373 | 0.99(0.90–1.09) | 0.795 | 1.03(0.91–1.17) |
| 6.0 | 1616(30.00) | 1.04(0.97–1.11) | 0.281 | 1.03(0.96–1.10) | 0.413 | 1.03(0.97–1.11) | 0.338 | 1.09(0.99–1.19) |
| 7.0 | 1702(30.26) | reference | reference | reference | reference | |||
| 8.0 | 6147(29.88) | 1.01(0.96–1.06) | 0.730 | 1.05(0.99–1.11) | 0.094 | 1.04(0.98–1.10) | 0.174 | 1.09(1.02–1.18) |
| ≥ 9 | 188(31.60) | 1.06(0.91–1.23) | 0.445 | 1.07(0.92–1.24) | 0.397 | 1.07(0.92–1.24) | 0.406 | 1.08(0.89–1.31) |
| LDL-C | ||||||||
| ≤ 5 | 405(19.46) | 1.03(0.92–1.15) | 0.643 | 1.02 (0.91–1.14) | 0.768 | 1.04(0.93–1.17) | 0.515 | 1.07(0.93–1.23) |
| 6.0 | 1031(19.14) | 1.03(0.94–1.12) | 0.540 | 1.02(0.94–1.12) | 0.584 | 1.03(0.94–1.12) | 0.532 | 1.08(0.98–1.21) |
| 7.0 | 1035(18.40) | reference | reference | reference | reference | |||
| 8.0 | 4269(20.75) | 1.18(1.10–1.26) | < 0.001 | 1.20(1.12–30) | < 0.001 | 1.21(1.12–1.30) | < 0.001 | 1.25(1.14–1.36) |
| ≥ 9 | 100(16.81) | 1.00(0.81–1.22) | 0.969 | 0.99(0.81–1.22) | 0.952 | 1.00(0.81–1.23) | 0.985 | 0.88(0.67–1.14) |
| HDL-C | ||||||||
| ≤ 5 | 1482(71.22) | 1.01(0.95–1.07) | 0.779 | 1.01(0.95–1.08) | 0.655 | 1.02(0.96–1.08) | 0.605 | 1.02(0.95–1.09) |
| 6.0 | 3658(67.90) | 1.01(0.97–1.06) | 0.570 | 1.02(0.97–1.06) | 0.505 | 1.01(0.97–1.06) | 0.579 | 1.02(0.96–1.07) |
| 7.0 | 3638(64.69) | reference | reference | reference | reference | |||
| 8.0 | 13,610(66.15) | 1.11(1.07–1.16) | < 0.001 | 1.11(1.07–1.15) | < 0.001 | 1.10(1.06–1.15) | < 0.001 | 1.11(1.06–1.16) |
| ≥ 9 | 412(69.24) | 1.27(1.15–1.41) | < 0.001 | 1.27(1.14–1.40) | < 0.001 | 1.24(1.12–1.38) | < 0.001 | 1.21(1.07–1.35) |
| Dyslipidemia | ||||||||
| ≤ 5 | 1298(62.37) | 0.96(0.90–1.02) | 0.166 | 0.96(0.90–1.02) | 0.955 | 0.98(0.92–1.04) | 0.471 | 0.99(0.92–1.08) |
| 6.0 | 3558(66.05) | 1.04(0.99–1.10) | 0.061 | 1.04(0.99–1.10) | 0.061 | 1.05(1.00–1.10) | 0.036 | 1.07(1.01–1.14) |
| 7.0 | 3695(65.70) | reference | reference | reference | reference | |||
| 8.0 | 13,081(63.58) | 0.95(0.92–0.99) | 0.012 | 1.01(0.97–1.05) | 0.564 | 1.01(0.97–1.05) | 0.509 | 1.08(1.02–1.14) |
| ≥ 9 | 379(63.70) | 0.98(0.88–1.09) | 0.681 | 0.98(0.88–1.09) | 0.706 | 0.98(0.88–1.09) | 0.685 | 1.08(0.95–1.24) |
Model 1 adjusted for age and sex
Model 2 was further adjusted for level of education, smoking, alcohol, physical activity, and snoring. Model 3 was further adjusted for hypertension, diabetes mellitus, body mass index, and high-sensitivity C-reactive protein
a Adjusted for model 3 and further excluded individuals with transient changes in lipid profile (e.g., reversion from dyslipidemia to normal blood lipid)