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. 2020 Aug 14;11:4084. doi: 10.1038/s41467-020-17915-w

Fig. 5. 2-HOBA reduces plasma inflammatory cytokines in hypercholesterolemic Ldlr−/− mice.

Fig. 5

a–d Inflammatory cytokines were measured in plasma from mice consuming a western diet for 16 weeks and treated with 2-HOBA, 4-HOBA, or vehicle. a IL-1β levels were measured by ELISA. n = 8 biologically independent mice per group. Data are presented as mean ± SEM. One-way ANOVA with Bonferroni’s post hoc test, p value of 2-HOBA vs vehicle is *0.0401 and 2-HOBA vs 4-HOBA is not significant. b IL-6 levels were measured by ELISA. n = 8 biologically independent mice per group. Data are presented as mean ± SEM. One-way ANOVA with Bonferroni’s post hoc test, p values of 2-HOBA vs 4-HOBA and 2-HOBA vs vehicle are ***<0.0001. c TNF-α levels were measured by ELISA. n = 8 (vehicle), 7 (4-HOBA), or 8 (2-HOBA) biologically independent mice. Data are presented as mean ± SEM. One-way ANOVA with Bonferroni’s post hoc test, p values of 2-HOBA vs 4-HOBA and 2-HOBA vs vehicle are *0.0385 and *0.0359. d The levels of SAA were measured by ELISA. n = 8 biologically independent mice per group. Data are presented as mean ± SEM. One-way ANOVA with Bonferroni’s post hoc test, p values of 2-HOBA vs 4-HOBA and 2-HOBA vs vehicle are **0.0025 and **0.0082. Source data are provided as a source data file.