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. 2020 Aug 14;11(8):630. doi: 10.1038/s41419-020-02866-3

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© The Author(s) 2020

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Fig. 6 — a–c Silibinin depleted ATP, glucose-6-phosph and pyruvate in a time-dependent manner. d Western blotting revealed that silibinin induced time-dependent downregulation of HK II, PFKP, and PKM2. e–g Pretreatment with GSH prevented silibinin-induced depletion of ATP, glucose-6-phosph, and pyruvate. h Western blotting proved that the downregulation of HK II, PFKP, PKM2, and p62 and the upregulation of ATG5 and LC3-II induced by silibinin were all inhibited in the presence of GSH. *p < 0.01 versus control group. The values are expressed as mean ± SEM (n = 5 per group).