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. 2020 Aug 14;11(8):631. doi: 10.1038/s41419-020-02860-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Timeline diagram of the experimental procedure used in b. Yap^flox/flox mice (control) and Yap^flox/flox;Rax-CreER^T2 mice (Yap CKO) received a single dose of 4-OHT at P10 and their retinas were analyzed at 12 months. b Analysis of the protein expression level of AQP4, Kir4.1, and GFAP. Results are normalised to α-tubulin (α-Tub) signal and expressed relative to control (n = 3 biological replicates per condition). c, d Retinal sections from 12-month-old control and Yap CKO mice immunostained for S-opsin (green) and PNA (red) (c) or M-opsin (green) and PNA (red) (d). Dorsal, central and ventral sections of retinal sections are shown. Nuclei are DAPI counterstained (blue). Scatter plots with bars represent the mean number of labelled cells per field (250 × 250 µm) from four retinas per condition. All values are expressed as the mean ± SEM. onl: outer nuclear layer, inl: inner nuclear layer, gcl: ganglion cell layer. Statistics: Mann–Whitney test, *p ≤ 0.05, **p ≤ 0.01, ns nonsignificant. Scale bars: 100 µm (central part) (enlarged panels) and 50 µm (dorsal and ventral part).