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. 2020 Aug 14;13:384. doi: 10.1186/s13104-020-05227-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Time (pass)-dependent effects of cocaine on BSR in the ICSS test. Upper and lower panels show data of % BSR thresholds (a) and data of % maximum wheel-spinning rates (b), respectively, according to the four post-drug treatment passes or time points (15, 30, 45 and 60 min). As described in the figure legend of Fig. 1 and following the same seven-pass ICSS paradigm, cocaine (5 mg/kg) or vehicle (saline) was injected subcutaneously at the end of pass 3 (the time point 0 min). The data of post-treatment BSR thresholds and maximum rates data at each of the four time points were normalized to pre-treatment baselines and presented as % BSR threshold and % maximum rate, respectively. Six mice were used for each experimental group. Data were presented as (mean ± SE) and analyzed by Repeated Measure two-way ANOVA with Bonferroni’s Multiple Comparison post hoc tests (*** p < 0.001)