Fig. 2.

Associations between CSF pTau and pTau/Aβ₄₀, Aβ PET, tau PET, neurodegeneration and cognition. Associations of baseline CSF pTau and pTau/Aβ₄₀ with baseline Aβ PET (a, b), baseline Temporal-metaROI FTP SUVR (c, d), baseline (e, f), and slope (g, h) of adjusted hippocampal volume (aHCV) (mm³), baseline (i, j) and slope (k, l) of PACC cognitive score. Different colors reflect the concordance and discordance between CSF pTau and CSF pTau/Aβ₄₀. For example, pTau−/pTau/Aβ₄₀− indicates the individual was negative according to both CSF pTau and CSF pTau/Aβ₄₀, while pTau+/pTau/Aβ₄₀− indicates the individual was positive according to CSF pTau but negative according to CSF pTau/Aβ₄₀