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. 2020 Aug 15;20:394. doi: 10.1186/s12935-020-01481-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — KCNQ1OT1, PD-L1 and CD8 were up-regulated, while miR-15a was down-regulated in PC tissues. a–c The expression levels of KCNQ1OT1 (a), miR-15a (b) and PD-L1 (c) were examined by RT-qPCR and compared between 30 pairs of PC tissues and the matching para-tumor normal tissues. d–f The correlations between KCNQ1OT1 and miR-15a (d), between miR-15a and PD-L1 (e), and between KCNQ1OT1 and PD-L1 (f) in PC tissues were examined using Spearman correlation analysis. g CD8 mRNA levels were examined by RT-qPCR and compared between 30 pairs of PC tissues and the matching para-tumor normal tissues. h The correlation between CD8 and PD-L1 in PC tissues was examined using Spearman correlation analysis. i CD8 protein level was examined by IHC. Representative images from PC tissue and the matching normal tissues were shown on the left and quantification of CD8 positive cells on the right. Scale bar: 50 µm. *P < 0.05, **P < 0.01 and ***P < 0.001