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Cytotoxicity of the FOLR1-targeting cp-Fab/CAR-T against IGROV-1 cells with titration of cp-Fabs based on tagged (a) or WT (b) h38C2 Fabs was tested at an E:T ratio of 10:1 and measured after 24 h incubation. Cytotoxicity mediated by the corresponding unprogrammed Fabs was also investigated. Shown are mean ± SD values from independent triplicates. The control experiments with untransduced T cells are shown in Supplementary Figure 4.
