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. Author manuscript; available in PMC: 2021 Jul 13.
Published in final edited form as: Angew Chem Int Ed Engl. 2020 May 18;59(29):12178–12185. doi: 10.1002/anie.202005432

Figure 5. In vivo activity of cp-Fab/CAR-T based on LCCT_1.

Figure 5.

(a) Four cohorts of NSG mice (n = 5) were inoculated with 1 × 106 IGROV-1/ffluc cells via i.p. injection. After 6 days, 2 × 107 CAR-Ts and LCCT_1 (1 μg or 10 μg) or unprogrammed LCCT (10 μg) or vehicle alone (PBS) were administered by the same route. The mice received a total of one dose of CAR-T and 10 doses of LCCT_1 or controls daily. (b) Starting on day 6, all 20 mice were imaged (see Supplementary Figure 8) and their radiance was recorded (mean ± SD). Significant differences between cohorts treated with LCCT_1 and PBS were calculated using an unpaired two-tailed t-test (*, p < 0.05; **, p < 0.01; ***, p < 0.001). (c) Corresponding Kaplan-Meier survival curves with p-values using a log-rank (Mantel-Cox) test (**, p < 0.01). (d) The weight of all 20 mice was recorded on the indicated days (mean ± SD).