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. 2020 Jun 8;11(8):1539–1547. doi: 10.1021/acsmedchemlett.0c00194

Table 2. Structure, Biophysical Properties, and Permeability of VHL-Targeting PROTACs (PROTAC Set 2).

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a

HSA % free, determined by HPLC method.

b

chromLogD7.4, determined by HPLC method.

c

PAMPA permeability/10–6 cm s–1.

d

Permeability/10–6 cm s–1.

e

Efflux Ratio. ND = Not determined.