Table 3. Blood Pharmacokinetic Parameters in Female Athymic MIA PaCa-2 Tumor-Bearing Nude Mice Following a Single IV Administrationa.
| CM03 (9.1 mg/kg) | CM03 (14 mg/kg) | SOP1812 (0.96 mg/kg) | |
|---|---|---|---|
| T1/2 (hr) | 33(21) | 16(7) | 37(8.0) |
| Clobs (mL/min/kg) | 10.9(2.7) | 8.1(4.0) | 2.2(1.0) |
| Vss (L/kg) | 5.2(0.9) | 2.2(0.4) | 1.2(0.4) |
| Vz (L/kg) | 27.8(10.7) | 11.8(10.4) | 6.9(3.0) |
| Cmax (ng/mL) | 4519(3240) | 22088(7407) | 4178(707) |
| AUCall (ng·h/mL) | 11113(2248) | 30628(13924) | 5863(1868) |
| AUCINF_obs (ng·h/mL) | 14484(3769) | 34356(17974) | 8271(3633) |
a
Three mice were in each group, and the data shown for each parameter are the mean values. Standard deviations are in parentheses.