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. 2020 Jul 16;11(8):1634–1644. doi: 10.1021/acsmedchemlett.0c00317

Table 4. Changes in Tumor Volume (TV) (cm3) Relative to Controls for the MIA PaCa-2 Xenograft Experiment (MTV: Mean Tumor Volume (cm3))a.

drug MTV ± SEM (day 28) % TV change (day 28) P value MTV ± SEM (day 53) % TV change (day 53) P value
CM03, 10 mg/kg, BiW 0.16 ± 0.20 –64.4 0.035* 0.63 ± 0.74 –60.6 0.574
CM03, 15 mg/kg, BiW 0.12 ± 0.19 –73.3 0.126 0.35 ± 0.59 –78.1 0.043*
SOP1812, 1 mg/kg, QW 0.08 ± 0.14 –82.2 0.020* 0.17 ± 0.33 –89.3 0.004***
SOP1812, 1 mg/kg, BiW 0.06 ± 0.08 –86.6 0.018* 0.15 ± 0.24 –90.6 0.008**
gemcitabine, 15 mg/kg, BiW 0.13 ± 0.07 –71.1 0.016* 0.39 ± 0.18 –75.6 0.004***
control 0.45 ± 0.18     1.60 ± 0.44    
a

Statistical analyses of average tumor volumes of treated versus control mice cohorts at the given time points used. Student’s t test: * P < 0.05, ** P < 0.01, *** P < 0.005.