Table 4. Changes in Tumor Volume (TV) (cm3) Relative to Controls for the MIA PaCa-2 Xenograft Experiment (MTV: Mean Tumor Volume (cm3))a.
| drug | MTV ± SEM (day 28) | % TV change (day 28) | P value | MTV ± SEM (day 53) | % TV change (day 53) | P value |
|---|---|---|---|---|---|---|
| CM03, 10 mg/kg, BiW | 0.16 ± 0.20 | –64.4 | 0.035* | 0.63 ± 0.74 | –60.6 | 0.574 |
| CM03, 15 mg/kg, BiW | 0.12 ± 0.19 | –73.3 | 0.126 | 0.35 ± 0.59 | –78.1 | 0.043* |
| SOP1812, 1 mg/kg, QW | 0.08 ± 0.14 | –82.2 | 0.020* | 0.17 ± 0.33 | –89.3 | 0.004*** |
| SOP1812, 1 mg/kg, BiW | 0.06 ± 0.08 | –86.6 | 0.018* | 0.15 ± 0.24 | –90.6 | 0.008** |
| gemcitabine, 15 mg/kg, BiW | 0.13 ± 0.07 | –71.1 | 0.016* | 0.39 ± 0.18 | –75.6 | 0.004*** |
| control | 0.45 ± 0.18 | 1.60 ± 0.44 |
a
Statistical analyses of average tumor volumes of treated versus control mice cohorts at the given time points used. Student’s t test: * P < 0.05, ** P < 0.01, *** P < 0.005.