Table 5. Results of the Transcriptome Study with SOP1812 and MIA PaCa-2 Cells: The Major Signalling Pathways Down-Regulated by CM03, SOP1812, and gemcitabine.

compound/time	no. of down-regulated genes	top affected signaling pathways
CM03 6 h	2203	Axon guidance, Hippo, Rap1, MAPK, endocytosis, insulin resistance, TNF, Wnt
CM03 24 h	2272	ErbB, neurotrophin, insulin, Rap1, mTOR, axon guidance, AMPK, TNF, Wnt
SOP1812 6 h	1423	Hippo, TNF, Rap1, NF-kappa B, Wnt
SOP1812 24 h	847	Axon guidance, cell cycle, DNA replication, Rap1, Wnt
gemcitabine 6 h	564	cell cycle, TNF, FoxO,
gemcitabine 24 h	1044	ribosome biogenesis, spliceosome, RNA transport, Hippo, Wnt