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. 2020 Jul 16;11(8):1634–1644. doi: 10.1021/acsmedchemlett.0c00317

Table 5. Results of the Transcriptome Study with SOP1812 and MIA PaCa-2 Cells: The Major Signalling Pathways Down-Regulated by CM03, SOP1812, and gemcitabine.

compound/time no. of down-regulated genes top affected signaling pathways
CM03 6 h 2203 Axon guidance, Hippo, Rap1, MAPK, endocytosis, insulin resistance, TNF, Wnt
CM03 24 h 2272 ErbB, neurotrophin, insulin, Rap1, mTOR, axon guidance, AMPK, TNF, Wnt
SOP1812 6 h 1423 Hippo, TNF, Rap1, NF-kappa B, Wnt
SOP1812 24 h 847 Axon guidance, cell cycle, DNA replication, Rap1, Wnt
gemcitabine 6 h 564 cell cycle, TNF, FoxO,
gemcitabine 24 h 1044 ribosome biogenesis, spliceosome, RNA transport, Hippo, Wnt