Table 6. Reduction in Expression in MIA PaCa-2 Cells for Selected Cancer-Related Genes Following Exposure to SOP1812, CM03, and Gemcitabine^a.

gene	Gem 6 h	Gem 24 h	CM03 6 h	CM03 24 h	SOP1812 6 h	SOP1812 24 h	protein function	no. of PQs
WNT5B	–0.56	0.06	–1.77	–0.97	–2.25	–0.57	promotes cancer cell migration, invasion	8
DVL1	–0.01	–0.26	–1.35	–1.31	–1.48	–0.77	key regulator of Wnt signaling pathway	30
AXIN1	–0.33	–0.11	–0.73	–1.43	–1.59	–0.39	negative regulator of β-catenin in Wnt pathway	18
APC2	–0.13	–0.57	–1.62	–1.38	–1.88	–1.06	regulator of Wnt signaling	38
GLI1	–0.52	–0.33	–0.61	–0.64	–0.66	–1.84	oncogenic PDAC transcription factor	15
MAPK11	0.10	0.61	–0.53	–2.56	–0.71	–1.72	essential effector kinase of p38 MAPK pathway	18
BCL-2	1.05	0.84	–1.12	–1.24	–0.58	–1.75	antiapoptosis gene	21
hTERT	–0.10	0.31	–1.66	–2.47	–2.29	–1.02	telomerase catalytic subunit	15

^aLog₂ FC fold changes in gene expression from RNA-seq analyses. Data for CM03 and gemcitabine are from ref (26). PQs are estimated numbers of putative quadruplex sites (ref (26)). Genes involved in the Wnt pathway are marked in bold.