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. 2020 Jul 16;11(8):1634–1644. doi: 10.1021/acsmedchemlett.0c00317

Table 6. Reduction in Expression in MIA PaCa-2 Cells for Selected Cancer-Related Genes Following Exposure to SOP1812, CM03, and Gemcitabinea.

gene Gem 6 h Gem 24 h CM03 6 h CM03 24 h SOP1812 6 h SOP1812 24 h protein function no. of PQs
WNT5B –0.56 0.06 –1.77 –0.97 –2.25 –0.57 promotes cancer cell migration, invasion 8
DVL1 –0.01 –0.26 –1.35 –1.31 –1.48 –0.77 key regulator of Wnt signaling pathway 30
AXIN1 –0.33 –0.11 –0.73 –1.43 –1.59 –0.39 negative regulator of β-catenin in Wnt pathway 18
APC2 –0.13 –0.57 –1.62 –1.38 –1.88 –1.06 regulator of Wnt signaling 38
GLI1 –0.52 –0.33 –0.61 –0.64 –0.66 –1.84 oncogenic PDAC transcription factor 15
MAPK11 0.10 0.61 –0.53 –2.56 –0.71 –1.72 essential effector kinase of p38 MAPK pathway 18
BCL-2 1.05 0.84 –1.12 –1.24 –0.58 –1.75 antiapoptosis gene 21
hTERT –0.10 0.31 –1.66 –2.47 –2.29 –1.02 telomerase catalytic subunit 15
a

Log2 FC fold changes in gene expression from RNA-seq analyses. Data for CM03 and gemcitabine are from ref (26). PQs are estimated numbers of putative quadruplex sites (ref (26)). Genes involved in the Wnt pathway are marked in bold.