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. 2020 Jul 6;11(8):1581–1587. doi: 10.1021/acsmedchemlett.0c00247

Figure 2.

Figure 2

Synthesis and comparison of substituted dihydrobenzofuran cores. Reagents and conditions: (a) Cinnamyl chloride, K2CO3, KI, acetone, reflux, 88%; (b) N,N-dimethylaniline, reflux, 55%; (c) MeNH2, THF, room temperature, 91%; (d) TFA, reflux, 6–16%.