Table 2.
Genes included in the top eight sub-categories of the KEGG pathway map. All genes in the top eight sub-categories that showed the most significance (p < 0.001) of the KEGG pathway in Fig. 7a are listed. Genes that were upregulated (+) or downregulated (−) relative to the control group are listed in each sub-category
| Map name | No of gene symbol | Gene symbol | Upregulated genes (control TMSC/culture-aged TMSC fc. (+)) | Downregulated genes (control TMSC/culture-aged TMSC fc. (−)) | p value |
|---|---|---|---|---|---|
| Axon guidance | 13 | PLXNA2, EPHA3, ROBO2, EPHB1, BMPR1B, EPHA5, EFNA5, SEMA6A, SLIT3, SEMA3E, SEMA3A, PAK3, TRPC4 | PLXNA2, EPHA3, ROBO2, EPHB1, BMPR1B, EPHA5, EFNA5, SEMA6A, SEMA3E, SEMA3A, PAK3, | SLIT3, TRPC4 | 4.88E-07 |
| PI3K-Akt signaling pathway | 23 | LPAR3, ITGA6, COL6A6, PDGFC, VEGFC, FGF5, IL7R, EFNA5, CREB5, CHRM2, HGF, RELN, CCNE2, TLR4, ITGA8, PDGFD, CDK2, ITGA7, KITLG, BRCA1, ITGB3, LAMA3, LAMA1 | LPAR3, ITGA6, PDGFC, VEGFC, FGF5, IL7R, EFNA5, CHRM2, RELN, CCNE2, TLR4, ITGA8, CDK2, KITLG, BRCA1, ITGB3, LAMA1 | COL6A6, CREB5, HGF, PDGFD, ITGA7, LAMA3 | 7.17E-12 |
| Pathways in cancer | 32 | CKS1B, TGFB2, SLC2A1, PTGER3, LPAR3, GSTM5, ITGA6, CASP8, AGTR1, HHIP, MAPK10, LEF1, VEGFC, FGF5, IL7R, HGF, CCNE2, DAPK1, CKS2, MAPK8, ETS1, CDK2, KITLG, BRCA2, BDKRB2, RAD51, BIRC5, LAMA3, LAMA1, NOTCH3, E2F1, PLCB1 | CKS1B, TGFB2, SLC2A1, LPAR3, GSTM5, ITGA6, AGTR1, HHIP, LEF1, VEGFC, FGF5, IL7R, CCNE2, CKS2, MAPK8, ETS1, CDK2, KITLG, BRCA2, RAD51, BIRC5, LAMA1, E2F1 | NOTCH3, PLCB1, PTGER3, CASP8, MAPK10, HGF, DAPK1, BDKRB2, LAMA3 | 2.02E-14 |
| ECM-receptor interaction | 11 | ITGA6, SDC1, COL6A6, HMMR, RELN, ITGA8, ITGA7, ITGB3, LAMA3, LAMA1, GP1BB | ITGA6, SDC1, HMMR, RELN, ITGA8, ITGB3, LAMA1, GP1BB | COL6A6, ITGA7, LAMA3 | 3.22E-08 |
| Protein digestion and absorption | 6 | COL3A1, DPP4, COL6A6, ELN, COL14A1, SLC1A1 | ELN | COL3A1, DPP4, COL6A6, COL14A1, SLC1A1 | 0.002749 |
| Rheumatoid arthritis | 5 | TGFB2, ATP6V1E2, TLR4, MMP3, TNFSF13B | TGFB2, ATP6V1E2, TLR4, MMP3 | TNFSF13B | 0.015019 |
| Hematopoietic cell lineage | 6 | IL1R1, ITGA6, IL7R, KITLG, ITGB3, GP1BB | ITGA6, IL7R, KITLG, ITGB3, GP1BB | IL1R1 | 0.003733 |
| Cytokine-cytokine receptor interaction | 15 | TGFB2, TNFSF4, IL1R1, ACKR3, IL1RAP, TNFSF10, BMPR1B, PDGFC, VEGFC, IL7R, CCL26, HGF, TNFRSF11B, KITLG, TNFSF13B | TGFB2, TNFSF4, IL1RAP, BMPR1B, PDGFC, VEGFC, IL7R, TNFRSF11B, KITLG | IL1R1, ACKR3, TNFSF10, CCL26, HGF, TNFSF13B | 1.34E-06 |