Table. 1.
IC50 of ANS–TAT–AuNPs and 6-MP–TAT–AuNPs after 24 h incubation and DRI of MCF-7/ADR cells.
Samples | IC50/μM * |
DRI (W/O VRP)* | DRI (W VRP)* | ||
---|---|---|---|---|---|
MCF-7 | MCF-7/ADR | MCF-7/ADR (W VRP)* | |||
ANS–TAT–AuNPs4.1nm | 9.0 ± 0.7 | 45.7 ± 3.5 | 19.5 ± 4.7 | 5.1 | 2.2 |
6-MP–TAT–AuNPs4.1nm | 7.4 ± 2.3 | 44.4 ± 6.5 | 20.2 ± 1.6 | 6.0 | 2.7 |
ANS–TAT–AuNPs5.4nm | 10.3 ± 1.2 | 25.2 ± 3.2 | 25.9 ± 4.2 | 2.4 | 2.5 |
6-MP–TAT–AuNPs5.4nm | 11.2 ± 1.5 | 20.5 ± 0.2 | 20.1 ± 2.2 | 1.8 | 1.8 |
calculated based on the concentration of ANS or 6-MP. W VRP: pre-treated with verapamil at 10 μM for 1 h; W/O VRP: without verapamil pre-treatment.