Table 2.
Association between CMI presence and cerebral perfusion adjusted for covariates.
| CBF (N = 148) B (95% CI) | p | CBFpvc (N = 148) B (95% CI) | p | Spatial CoV (N = 181) B (95% CI) | p | |
|---|---|---|---|---|---|---|
| Model 1: CMI presence | −6.1 (−11.1; −1.2) | .016 | −6.5 (−12.9; −.2) | .044 | .08 (.02; .14) | .006 |
| Model 2: CMI + age, sex | −5.0 (−9.7; −.2) | .038 | −5.6 (−11.9; .6) | .078 | .06 (.003; .11) | .039 |
| Model 3: CMI + age, sex + | ||||||
| Hypertension | −4.6 (−9.3; .1) | .054 | −5.1 (−11.4; 1.1) | .106 | .05 (−.005; .10) | .079 |
| Hypercholesterolemia | −4.4 (−9.3; .4) | .073 | −4.8 (11.2; 1.6) | .143 | .05 (−.006; .10) | .082 |
| Diabetes | −4.5 (−9.3; .2) | .061 | −5.3 (−11.7; 1.0) | .098 | .06 (.003; .11) | .040 |
| Current smoking | −5.2 (−9.9; −.4)) | .033 | 5.8 (−12.1; .5) | .072 | .05 (.001; .11) | .045 |
| Obesity | −5.0 (−9.9; −.1) | .044 | −6.2 (−12.7; .4) | .064 | .06 (.004; .11) | .034 |
| History of stroke | −5.7 (−10.5; −1.0) | .018 | −4.9 (−11.2; 1.4) | .126 | .05 (.001; .11) | .047 |
| Cardiac disease | −4.5 (−9.2; .3) | .065 | −6.4 (−12.7; −.1) | .048 | .05 (−.01; .10) | .122 |
| All vascular risk factors | −4.8 (−9.8; .3) | .066 | −5.7 (−12.5; 1.0) | .096 | .05 (−.005; .11) | .075 |
| Model 4: CMI + age, sex + | ||||||
| Total brain volume | −3.7 (−8.2; .8) | .110 | −4.5 (−10.7; 1.7) | .154 | .04 (−.01; .10) | .104 |
| WMH volumea | −3.1 (−7.8; 1.7) | .200 | −3.6 (−10.0; 2.8) | .265 | .03 (−.02; .09) | .210 |
| Presence of cortical infarcts | −5.0 (−10.0; −.1) | .045 | −5.6 (−12.2; .9) | .090 | .05 (−.003; .11) | .064 |
| Presence of subcortical infarcts | −4.6 (−9.5; .2) | .059 | −5.0 (−11.4; 1.4) | .122 | .05 (−.001; .11) | .048 |
| Presence of microbleeds | −4.2 (−8.9; .6) | .086 | −4.4 (−10.7; 1.9) | .171 | .05 (−.004; .10) | .069 |
| Presence intracranial stenosis | −4.4 (−9.2; .4) | .073 | −5.0 (−11.4; 1.5) | .128 | .05 (−.003; .10) | .064 |
| All imaging markers | −1.1 (−6.0; 3.9) | .670 | −1.2 (−8.1; 5.6) | .727 | .02 (−.04; .07) | .581 |
CBF: cerebral blood flow; CBFpvc: partial volume corrected cerebral blood flow; spatial CoV: spatial coefficient of variation of the cerebral blood flow; CMI: cerebral cortical microinfarct; WMH: white matter hyperintensity.
Data presented as B: mean difference between patients with and without CMIs and the 95% confidence interval. Model 1: unadjusted; model 2: adjusted for age and sex; model 3: adjusted for age, sex and each individual vascular risk factor added separately; model 4: adjusted for age, sex and each individual neuro-imaging marker added separately.
a
WMH volume was entered into the analysis after a logarithmic transformation of the data.