Table 4.
Risk factors for relapse and death in patients with Gram-negative bacteria catheter-related bloodstream infection
| Characteristics | Relapse | Death | ||||||
|---|---|---|---|---|---|---|---|---|
| Yes (N = 9) |
No (N = 131) |
p-value | Multivariate analysis OR (95% CI), p-value |
Yes (N = 34) |
No (N = 106) |
p-value | Multivariate analysis OR (95% CI), p-value |
|
| Age | 69 | 66 | 0.171 | 63 | 67 | 0.800 | ||
| Sex | ||||||||
| Male | 5 | 73 | 1.000 | 22 | 56 | 0.241 | ||
| Female | 4 | 58 | 12 | 50 | ||||
| Charlson comorbidity index | 7 | 5 | 0.075 | 5 | 6 | 0.694 | ||
| Underlying diseases | ||||||||
| HIV infection | 0 | 1 | 1.000 | 0 | 1 | 1.000 | ||
| Cancer | 4 | 35 | 0.264 | 13 | 26 | 0.130 | ||
| Liver disease | 0 | 10 | 1.000 | 4 | 6 | 0.256 | ||
| Renal disease | 5 | 49 | 0.307 | 7 | 47 | 0.015a | 0.630 (0.216–1.895) 0.420 | |
| COPD | 1 | 6 | 0.379 | 2 | 5 | 0.677 | ||
| Diabetes mellitus | 6 | 43 | 0.066 | 7 | 42 | 0.062 | ||
| Hematological disease | 1 | 11 | 0.565 | 6 | 6 | 0.071 | ||
| Cardiovascular disease | 3 | 25 | 0.383 | 5 | 23 | 0.465 | ||
| Trauma | 0 | 5 | 1.000 | 3 | 2 | 0.092 | ||
| Immunocompromised status | 2 | 30 | 1.000 | 11 | 21 | 0.160 | ||
| Microbial etiology | ||||||||
| Monomicrobial | 9 | 124 | 1.000 | 32 | 101 | 0.677 | ||
| Polymicrobial | 0 | 7 | 2 | 5 | ||||
| Origin of infection | ||||||||
| Healthcare-associated | 3 | 28 | 0.415 | 0 | 31 | < 0.001a | 266,606,914.2 (< 0.001-infinity) 0.998 | |
| Nosocomial | 6 | 103 | 34 | 75 | ||||
| ICU admission at onset of infection | 1 | 70 | 0.017a | 0.173 (0.005–6.394), 0.341 | 26 | 45 | 0.001a | 1.803 (0.590–5.512) 0.301 |
| Surgery at present admission | 2 | 74 | 0.080 | 24 | 52 | 0.031a | 0.763 (0.279–2.086) 0.598 | |
| Type of catheter | ||||||||
| Tunneled hemodialysis catheter | 5 | 27 | 0.029a | 10.023 (0.559–179.714), 0.118 | 1 | 31 | 0.001a | 1.013 (0.074–13.929) 0.992 |
| Short-term central venous catheter or arterial catheter | 2 | 79 | 0.036a | 2.320 (0.072–74.855), 0.635 | 29 | 52 | < 0.001a | 2.214 (0.599–8.187) 0.233 |
| Long-term central venous catheter or port | 2 | 25 | 0.684 | 4 | 23 | 0.317 | ||
| Catheter management | ||||||||
| Catheter retention | 7 | 4 | < 0.001a | 145.315 (12.665–1667.369), < 0.001a | 4 | 7 | 0.462 | |
| Catheter removal | 2 | 127 | 30 | 99 | ||||
| Total duration of therapy | 14 | 16 | 0.269 | 0.855 (0.623–1.172) 0.330 | 15 | 16 | 0.264 | 0.990 (0.923–1.062) 0.781 |
| Duration of therapy after catheter removal | 13 | 14 | 0.946 | 11 | 14 | 0.039a | ||
ap-value < 0.05
Abbreviations: HIV human immunodeficiency virus, COPD chronic obstructive pulmonary disease, ICU intensive care unit
Data were presented as count except age, Charlson comorbidity index, total duration of therapy, duration of therapy after catheter removal, which were presented as median