Table 3.

Model-Based Reproduction Numbers, Immunity Thresholds for Eradication of Vaccine-Covered Oncogenic Human Papillomaviruses (HPVs), and Corresponding Critical Coverage of Vaccination by Vaccine Efficacy for Gender-Neutral (Girls and Boys) and Girls-Only (Girls) Vaccination Strategies

	Reproduction Numbera		Immunity Threshold		Critical Coverage of Vaccination
					VE 95%		VE 80%		VE 50%
HPV Type	Girls and Boys	Girls	Girls and Boys	Girls	Girls and Boys	Girls	Girls and Boys	Girls	Girls and Boys	Girls
HPV16	3.3	10	70%	90%	74%	95%	88%	NEb	NEb	NEb
HPV18	2.2	4.5	55%	78%	58%	82%	69%	98%	NEb	NEb
HPV31/33	1.7	2.9	40%	65%	42%	68%	50%	81%	80%	NEb
HPV45	1.7	2.9	40%	65%	42%	68%	50%	81%	80%	NEb
HPV35	1.3	1.5	20%	35%	21%	37%	25%	44%	40%	70%

Abbreviations: NE, no eradication; VE, vaccine efficacy.

^aReproduction number (R0) is calculated by determining the immunity threshold using the transmission model with a computational vaccine with 100% efficacy. In the gender-neutral vaccination strategy (girls and boys), R0 is from girls/boys to boys/girls. In the girls-only vaccination strategy (girls) R0 is from girls to girls (via boys, heterosexual model).

^bNE = no eradication even with a 100% coverage of vaccination.