Figure 2.

The impact of memantine on some RBC-related parameters. Means and 95%-CIs of RBC count, Hb, reticulocyte count, lactate dehydrogenase (LDH) activity, ferritin and total bilirubin in plasma as well as percentage of hypochromic and hyperchromic RBC isolated from patients 1 to 4 before enrolment and during the trial are shown. Note that the ferritin values for P4 reach levels around 1500 μg/l and thus are not shown here but appear in Table S2. Screening has no 95%-CI since there is only one measurement. Symbols (dot, ^∗,^∗∗,^∗∗∗ meaning p < 0.1, p < 0.05, p < 0.01, p < 0.001, respectively; values are compared with screening value using Welch t test, not adjusted.). Periods: Pre = pre-screening, Scr = screening, Up = up-titration, Trt = treatment, Dwn = down-titration, Fup = follow-up.