Table 1.

List of statins as a single-ingredient product licensed by the Food & Drug Administration and European Medicines Agency

Statin	Solubility	Type	Synthetic state	Pharmacokinetic parameters
				Cytochrome P450 subclass	Half-life (hours)		Clearance (L/hour)				Hepatic extraction	Excretion
							Systemic	Oral	Hepatic	Renal		Urine	Faecal
Atorvastatin	Lipophilic	Fully synthetic	Active drug	CYP3A4	Mean*	17.8		157			>70%	1.20%	70%
					Range†	13.8–20.7
Lipitor‡					Dose§: 20, 40, 80 mg			REF: 58			REF: 59	REF: 58	REF: 60
					REF: 61 62
Cerivastatin	Lipophilic	Fully synthetic	Active drug	CYP2C8 and CYP3A4	Mean*	2.96	13					24%–30%	70%
					Range†	2.2–4.0
Lipobay‡¶					Dose§: 0.2 to 0.3 mg
					REF: 63–65		REF: 63					REF: 66 67	REF: 66 67
Fluvastatin	Lipophilic	Natural statin	Active drug	CYP2C9 some CYP2C8	Mean*	1.9	68	120–180	69		73%	6%	93%
					Range†	1.5–2.4
Lescol‡					Dose§: 40 to 80 mg		REF: 68	REF: 69 70	REF: 71		REF: 72	REF: 68	REF: 68
					REF: 73–76
Lovastatin	Lipophilic	Natural statin	Prodrug	CYP3A4	Mean*	2.7	18–75	175–351			69%	9.60%	83.20%
					Range†	2.6–2.8
Mevacor‡**					Dose§: 20 to 40 mg		REF: 71	REF: 69 77 78 78			REF: 79	REF: 71	REF: 71
					REF: 76 78 80
Pitavastatin	Lipophilic	Fully synthetic	Active drug	Partially: CYP2C8 and CYP2C9	Mean*	10.7		16–26				15%	79%
					Range†	6.9–13.1
Livalo‡					Dose§: 1, 2, 4 mg			REF: 81–84				REF: 85	REF: 85
					REF: 81–84 86 87
Rosuvastatin	Hydrophilic	Fully synthetic	Active drug	Partially: CYP2CP and CYPC19	Mean*	14.2	49	273–281	82	12	63%	5%–10%	90%
					Range†	10.1–24.4
Crestor‡					Dose§: 5, 10, 20, 40 mg
					REF: 88–93		REF: 94	REF: 88	REF: 95	REF: 94	REF: 94	REF: 94 96	REF: 96
Pravastatin	Hydrophilic	Semisynthetic	Active drug	None	Mean*	2.17	57			24–27	46%–66%	20%	71%
					Range†	1.6–2.6
Pravachol‡					Dose§: 10, 20, 40 mg		REF: 97			REF: 97–99	REF: 59	REF: 97	REF: 97
					REF: 80 97 100–103
Simvastatin	Lipophilic	Semisynthetic	Prodrug	CYP3A4	Mean*	4.6	32	2000–3100			>79%	13%	58%
					Range†	1.6–7.9
Zocor‡					Dose§: 20, 40, 60 mg		REF: 104	REF:105–107			REF:79	REF: 104 108	REF:104 108
					REF: 92 105 106 109–115

Cerivastatin is withdrawn from the market and lovastatin is not licensed in Great Briatin and Switzerland

*Mean calculated as the average of the means of the cited references.

†Range of the means from the cited references.

‡Common brand name.

§Half-life reported from indicated doses from the cited references.

¶Withdrawn from the market due to rhabdomyolysis in 2001.

**Not commonly prescribed anymore and not licensed in Great Britain and Switzerland.