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Agonist, antagonist, and opioid effects on dopamine D1 and D4.4 receptor–mediated adenylyl cyclase. (A) D1 agonist stimulation of adenylyl cyclase. (B) D1 antagonist inhibition of 100 nM dihydrexidine-stimulated adenylyl cyclase activity. (C) D4.4 agonist inhibition of 10 µM forskolin-stimulated adenylyl cyclase. (D) D4.4 antagonist reversal of 2 nM quinpirole inhibition of forskolin-stimulated adenylyl cyclase. Data shown are the means ± S.E.M. of three to six experiments.
