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. 2020 Sep;374(3):354–365. doi: 10.1124/jpet.119.264127

Fig. 3.

Fig. 3.

Cellular uptake of Mel-lip, Mel-Tf-lip, kFGF-lip, kFGF-Tf-lip, PasR8-lip, and PasR8-Tf-lip. The amount of 1,1'-Dioctadecyl-3,3,3',3'-Tetramethylindocarbocyanine Perchlorate (DiI)-labeled liposomes incorporated into bEnd.3 cells (A), primary astrocytes (B), and primary neurons (C) was measured after 0.1, 0.25, 0.5, 1, and 4 hours of incubation. ***P < 0.05 compared with liposome uptake after 4 hours of incubation. The amount of 1,1'-Dioctadecyl-3,3,3',3'-Tetramethylindocarbocyanine Perchlorate (DiI)-labeled liposomes incorporated after 4 hours of incubation into bEnd.3 cells (D), primary astrocytes (E), and primary neurons (F) pretreated with endocytosis inhibitors (sodium azide, chlorpromazine, amiloride, and colchicine). All data are expressed as means ± S.D. (n = 4). ***P < 0.05 compared with control group (4 hours of incubation without endocytosis inhibitors).