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. 2020 Aug 13;8(2):e000927. doi: 10.1136/jitc-2020-000927

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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Adverse events of BCMA CAR-T cell therapy in R/R MM. (A) Fold change (peak concentration compared with baseline) of serum cytokines (IL-6, IL-10, and interferon (IFN)-γ), ferritin, and CRP after CAR-T cells infusion in patients with MM. (B, C) Changes in the levels of cytokines, serum ferritin, and serum CRP in representative cases (patient 1 and patient 5) after CAR-T cells infusion. (D) Changes in serum immunoglobulin (Ig)A (normal range, 90 to 450 mg/dL), IgG (normal range, 800 to 1800 mg/dL), and IgM (normal range, 60 to 280 mg/dL) levels after CAR-T cell therapy. BCMA, B cell maturation antigen; CAR, chimeric antigen receptor; CRP, C-reactive protein; MM, multiple myeloma; R/R, refractory/relapsed.