Table 2.
Baseline characteristics and outcomes
Patient | HBsAg | HBsAb | HBeAg | HBeAb | HBcAb | HBV DNA, IU/mL |
ALT, U/L |
AST, U/L |
Bilirubin total µM |
Albumin, G/L | Previous heap hepatitis | Antivira therapy | HBsAg* | HBsAb* | HBeAg* | HBeAb* | HBcAb* | HBV DNA, IU/mL* |
1 | Negative | Negative | Negative | Positive | Positive | <100 | 14 | 23 | 9.6 | 33.9 | Yes | No | Negative | Positive | Negative | Negative | Positive | <100 |
2 | Negative | Positive | Negative | Negative | Positive | <100 | 7 | 13 | 7.5 | 34.2 | Yes | Entecavir | Negative | Negative | Negative | Negative | Negative | NA |
3 | Negative | Negative | Negative | Negative | Positive | <100 | 14 | 8 | 15.9 | 49.6 | Yes | Lamivudine | Negative | Positive | Negative | Negative | Positive | <100 |
4 | Negative | Positive | Negative | Positive | Positive | <100 | 11 | 12 | 9.1 | 42.6 | Yes | No | Negative | Positive | Negative | Negative | Negative | <100 |
5 | Negative | Positive | Negative | Negative | Positive | NA | 15 | 18 | 14.7 | 40.2 | Yes | No | Negative | Positive | Negative | Negative | Negative | NA |
6 | Positive | Negative | Negative | Positive | Positive | <100 | 21 | 32 | 11.5 | 38.9 | Yes | Entecavir/ Lamivudine |
Positive | Negative | Negative | Positive | Positive | <100 |
7 | Negative | Positive | Negative | Positive | Positive | NA | 37 | 20 | 11.3 | 36.2 | Yes | No | Negative | Positive | Negative | Negative | Negative | <100 |
8 | Negative | Positive | Negative | Negative | Positive | NA | 9 | 15 | 4.8 | 36.8 | Yes | No | Negative | Positive | Negative | Negative | Positive | NA |
9 | Negative | Positive | Negative | Negative | Positive | <100 | 10 | 15 | 7.3 | 41.8 | Yes | No | Positive | Negative | Negative | Negative | Positive | <100 |
*Immunological detection of HBV in serum after BCMA CAR-T infusion in 6 to 12 months.
ALT, alanine transferase; AST, aspartate transaminase; BCMA, B cell maturation antigen; CAR, chimeric antigen receptor; HBcAb, hepatitis B core antibody; HBeAb, hepatitis B e antibody; HBeAg, hepatitis B e antigen; HBsAb, hepatitis B surface antigen; HBsAg, hepatitis B surface antigen; HBV, hepatitis B virus; NA, not applicable.