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[Preprint]. 2020 Oct 30:2020.08.13.250217. Originally published 2020 Aug 14. [Version 2] doi: 10.1101/2020.08.13.250217

Fig. 1. Anesthetics and hydroxychloroquine inhibit SARS2-PV entry.

Fig. 1.

(A) Chemical structures comparing chloroquine (CQ) and hydroxychloroquine (HCQ) to tetracaine, a local anesthetic. (B-C) SARS-CoV-2 pseudovirus (SARS2-PV) entry assay measured as a percent of control luciferase activity. HCQ (50 μM), tetracaine (50 μM) and propofol (50 μM) inhibited viral infection in ACE2 overexpressing HEK293T cells without (B) and with (C) cholesterol loading (4 μM apolipoprotein E + 10% serum). Data are expressed as mean ± s.e.m., *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001, one-way ANOVA, n=4–6.