Figure 7. A).

A) The frequency of missense mutations in regions targeted by diagnostic PCR tests is linked to constraints imposed by coded protein structures while the frequency of synonymous mutations remains roughly the same. B) Examples of the effects of constrains imposed by proteins on frequency of mutations in 2019-nCoV_N1 PCR test and nCoV_2019 whose target region code for disorder linker region in Nucleocapsid protein and to significantly under mutated RNA-dependent RNA polymerase (RdRP).