Table 1.

SARS-CoV-2 proteins with frequency of mutations significantly different from the background (proteome). The Bonferroni corrected significance threshold is 0.0019. “n/s” – p-values not significant even before the correction. P-values indicating significance are shown in bold font.

			Non-structural proteins / structural ORFs background		Proteome background
Protein name	Length (nt)	# missense mutations	p-value greater	p-value less	p-value greater	p-value less
surface glycoprotein	3822	762	n/s	1.69E-28	n/s	n/s
membrane glycoprotein	669	117	n/s	2.30E-07	n/s	n/s
nsp12	2795	416	n/s	5.45E-06	n/s	2.04E-13
ORF8b protein	366	128	0.0015	n/s	1.59E-08	n/s
nsp1	540	133	0.00035	n/s	0.02	n/s
ORF14 protein	222	90	9.69E-05	n/s	3.80E-09	n/s
nucleocapsid phosphoprotein	1260	438	4.01E-09	n/s	1.96E-25	n/s
ORF3a protein	828	330	2.50E-13	n/s	1.76E-28	n/s
nsp2	1914	493	4.01E-15	n/s	3.18E-07	n/s