Table 2.

Structurally characterized protein domains with frequency of mutations significantly different than the background (the encompassing full protein). The Bonferroni corrected significance threshold is 0.0018. “n/s” – p-values not significant even before the correction. P-values indicating significance are shown in bold font.

Domain	Protein	Domain length	No. of missense mutations in domain	No. of missense mutations in protein	Protein length	p-value from binomial test
						Over-mutation	Under-mutation
6vyoA	Nucleocapsid	372	86	438	1260	n/s	1.62E-06
6wjiA	Nucleocapsid	324	83	438	1260	n/s	0.00052
Region b/w 6vyoA and 6wjiA	Nucleocapsid	249	119	438	1260	0.00011	n/s
Region b/w Spike start and 6lzgB	Spike	996	259	762	3822	7.4E-07	n/s
Region b/w 2griA and 6w02A	nsp3	288	85	1103	5835	4.84E-05	n/s