Table 3.

Structurally characterized protein subdomains with frequency of mutations significantly different than the background (the encompassing full protein domain – experimentally characterized structure). The Bonferroni corrected significance threshold is 0.0019 “n/s” – p-values not significant even before the correction. P-values indicating significance are shown in bold font.

PDB ID of corresp. domain	Subdomain	Subdomain length	No. of missense mutations in subdomain	No. of missense mutations in corresponding domain	Corresp. domain length	p-value from binomial test
						Over-mutation	Under-mutation
Nsp3/2w2gA	I	384	81	131	792	0.0014	n/s
Nsp3/2w2gA	II	387	48	131	792	n/s	0.0032