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[Preprint]. 2020 Aug 10:2020.08.10.244756. [Version 1] doi: 10.1101/2020.08.10.244756

Table 3.

Structurally characterized protein subdomains with frequency of mutations significantly different than the background (the encompassing full protein domain – experimentally characterized structure). The Bonferroni corrected significance threshold is 0.0019 “n/s” – p-values not significant even before the correction. P-values indicating significance are shown in bold font.

PDB ID of corresp. domain Subdomain Subdomain length No. of missense mutations in subdomain No. of missense mutations in corresponding domain Corresp. domain length p-value from binomial test
Over-mutation Under-mutation
Nsp3/2w2gA I 384 81 131 792 0.0014 n/s
Nsp3/2w2gA II 387 48 131 792 n/s 0.0032