Table 3.
Structurally characterized protein subdomains with frequency of mutations significantly different than the background (the encompassing full protein domain – experimentally characterized structure). The Bonferroni corrected significance threshold is 0.0019 “n/s” – p-values not significant even before the correction. P-values indicating significance are shown in bold font.
PDB ID of corresp. domain | Subdomain | Subdomain length | No. of missense mutations in subdomain | No. of missense mutations in corresponding domain | Corresp. domain length | p-value from binomial test | |
---|---|---|---|---|---|---|---|
Over-mutation | Under-mutation | ||||||
Nsp3/2w2gA | I | 384 | 81 | 131 | 792 | 0.0014 | n/s |
Nsp3/2w2gA | II | 387 | 48 | 131 | 792 | n/s | 0.0032 |