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[Preprint]. 2020 Aug 11:rs.3.rs-55764. [Version 1] doi: 10.21203/rs.3.rs-55764/v1

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Lipid mediators down-regulate injury-induced gene expression of NFkB/inflammation, senescence-associated secretory phenotype, and cytokine storm markers after cornea injury. a, Venn diagram of cytokines, SASP, and NFkB inflammatory genes upregulated by injury. b, Heatmap of normalized counts data. Each small square represents data from one cornea. There are 51 genes increased by injury, and most are inhibited by ELV-N32 and RvD6i treatment. c, The ArchS4 human tissue analysis prediction for the 51 genes. The length of the bar represents the significance of the gene set in the tissues, while the lighter the color, the higher the significance. The number shows the amount of genes from the denoted group enriched in each pathway. d, Scatter plots of Il1b, Il6, and Vegfa genes. e, Scatter plots of genes that encode proteins that target RGD. The p-value of ANOVA-post hoc Dunnett's multiple comparisons test with vehicle as reference are shown. Mean and SD are depicted as the lines. The normalized counts were used for analysis.