Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 1;48(14):8074–8089. doi: 10.1093/nar/gkaa549

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Figure 2. — U3-derived small RNA fragment sequences are bound by components of the miRNA biogenesis machinery. (A) The normalised number of reads mapping to each nucleotide of the U3 sequence in (PAR-)CLIP analysis of snoRNP proteins (upper panel; FBL - fibrillarin) and miRNA-associated proteins (lower panel; AGO - Argonaute) is shown as a percentage of the maximum (Per. Max) above a schematic model of the U3 snoRNA. (B) Schematic secondary structure of the U3 snoRNA within the U3 snoRNP. Evolutionarily conserved features of the snoRNA are indicated. (C) Schematic secondary structure of the U3 snoRNA within the U3 snoRNP. Evolutionarily conserved features of the snoRNA. The hairpin containing of Dicer-associated sequences present in the small RNA-seq/CLIP libraries is marked in green and the guide strand of the putative miRNA duplex is indicated in orange.