Table 5. Summary of clinical laboratory results associated with pathogen groups.
Clinical laboratory values were compared for patients with different infectious etiologies as described above. All tests of statistical significance were two-tailed, and significance was defined as p<0.05. Values are medians (IQR). Bolded value with asterisk indicates the value is significantly different from patients without the indicated pathogen. Note: WBC, White Blood Count; Hgb, Hemoglobin; Hct, Hematocrit; Na, Sodium; K, Potassium; Ca, Total Calcium; Cl, Chloride; BUN, Blood Urea Nitrogen; Cr, Creatinine; Glu, Glucose; Tbil, Bilirubin; Tp, Total Protein; ALB, Albumin; AST, Aspartate aminotransferase; ALT, Alanine Aminotransferase.
| Clinical lab | None (N = 107) |
B. pseudomallei (N = 23) |
Dengue virus (N = 21) |
O. tsutsugamushi (N = 16) |
SFG (N = 12) |
Leptospira spp. (N = 10) |
K. pneumoniae (N = 8) |
AFB (N = 7) |
E. coli (N = 5) |
|---|---|---|---|---|---|---|---|---|---|
| WBC (cells/μl) | 12.3×103 (8–17.6) | 14.3×103 (9.7–18.5) |
11×103 (9–16) | 11.1×103 (8.8–12.8) |
12.8×103 (10.8–21.6) | 10.7x103 (9.8–12.1) | 12.3×103 (11.1–27) |
11.5×103 (9.2–13.9) | 14.6×103 (9.7–20.1) |
| Granulocyte % | 83 (75–88) |
84 (77–88) |
80 (65–83) |
77 (71–83) |
81 (75–87) |
83 (77–87) | 81 (73–87) |
76 (67–83) |
85 (83–90) |
| Lymph/Mono Count (cells/μl) | 2×103 (1.5–2.8) | 1.9×103 (1.5–2.9) |
2.2×103 (1.7–3.1) | 2.25×103 (1.7–2.9) |
2.5×103 (1.9–3.9) | 1.8x103 (1.7–2.3) | 2.7×103 (2.2–3.5) |
2.2×103 (2.2–3) | 2.7×103 (1.4–3.1) |
| Hgb (g/dl) | 12.4 (10.8–13.7) | 11.9 (11–14.2) | 12.7(11.8–13.9) | 11.8 (10.8–12.9) | 11.8 (10.9–12.3) | 12 (9.6–12.8) | 13.5 (11.7–14.7) | 12.6 (11.4–14.6) | 11.6 (10.7–11.9) |
| Hct (%) | 38 (33–42) | 36 (34–44) | 39 (36–42) | 36 (33–40) | 37 (34–38) | 38 (29–41) | 40 (32–45) | 42 (36–47) | 32 (32–37) |
| Platelet (per μl) | 2.87×105 (2.02–4.24) | 2.27×105 (1.76–2.96) | 2×105 (1.52–2.49) | 1.41×105 (1.07–2.28) |
3.17×105 (1.82–3.66) | 1.75x105 (1.3–3) | 2.79×105 (1.50–7.53) | 6.54×105 (5.88–7.58)* | 1.15×105 (1.11–2.04) |
| Na (mmol/L) | 135 (132–138) | 131 (124–133)* | 136 (133.5–139) | 133 (129–138) | 136.5 (135–138.5) | 135 (133–137) | 133 (129–134) | 130 (129–133)* | 135 (133–137) |
| K (mmol/L) | 3.6 (3.1–4.2) | 3.9 (3–4.5) | 3.8 (3.4–4.4) | 3.9 (3.3–4.3) | 3.7 (3.2–4) | 3.3 (2.4–3.5) | 4.4 (3.2–5.3) | 4.3 (3.2–4.4) | 3.3 (2.6–3.8) |
| Ca (mg/dL) | 2.2 (2.1–2.3) | 2.1 (2–2.3) | 2.1 (2.1–2.2) | 2.1 (1.9–2.1)* | 2.1 (2.1–2.3) | 2.1 (2–2.2) | 2.3 (2.1–2.4) | 2.3 (2.1–2.5) | 2.2 (2.2–2.2) |
| Cl (mmol/L) | 97 (94–101) | 93 (88–97)* | 98 (96–101) | 98 (95–101) | 98 (98–102) | 98 (93–102) | 95 (89–99) | 91 (90–93)* | 101 (99–101) |
| BUN (mg/dL) | 12 (9–15) | 13 (10–17) | 13 (11–20) | 17 (11.5–21.5)* | 10.5 (7–14) | 12.5 (9–17) | 13.5 (10.5–22) | 11.5 (9–15) | 14 (9–25) |
| Cr (mg/dL) | 0.9 (0.7–1) | 0.8 (0.7–1) | 1 (0.9–1.3) | 1 (0.9–1.5) | 0.9 (0.8–1) | 0.9 (0.7–1) | 0.8 (0.5–0.9) | 0.5 (0.5–0.6)* | 1.1 (0.7–1.6) |
| Glu (mg/dL) | 111 (93–135) | 172 (110–330)* | 110 (95–138) | 99 (89.5–150) | 109 (94–151) | 131 (99–156) | 122 (109–307) | 111 (93–166) | 99 (89–125) |
| Tbil (mg/dL) | 0.8 (0.6–1.1) | 0.9 (0.6–1.7) | 0.9 (0.6–1.2) | .9 (0.65–3.3) | 0.9 (0.6–2.5) | 0.7 (0.6–0.9) | 0.75 (0.6–1.1) | 2.1 (0.6–3.6) | 1 (0.5–4.9) |
| Tp (g/dL) | 7.5 (7–8.1) | 7.2 (6.6–7.7) | 6.9 (6.2–7.8) | 6.4 (5.6–7.4)* | 7.1 (6.2–7.6) | 6.5 (6.2–7.5) | 7.8 (7.4–8.7) | 7 (6.8–7.9) | 7.8 (6.8–8.7) |
| Alb (g/dL) | 3.1 (2.7–3.5) | 2.5 (2.3–3.1) | 2.8 (2.3–3.3) | 2.4 (2–2.8)* | 2.6 (2.4–3.1) | 2.5 (2–3)* | 2.6 (2.5–3.8) | 2.5 (2.2–2.6) | 3.1 (2.5–3.1) |
| AST (U/L) | 55 (35–100) | 58 (52–133) | 67 (49–170) | 154.5 (51.5–185.5)* | 42 (32–155) | 56 (45–76) | 40 (32–56)* | 100 (46–249) | 56 (40–68) |
| ALT (U/L) | 40 (25–74) | 59 (32–95) | 55 (38–85) | 77.5 (45.5–116) | 64 (30–95) | 35.5 (19–52) | 28 (25–43) | 83 (44–159) | 50.5 (32.5–73.5) |
| Lactate | 21 (15.8–26.8) | 23.2 (15.1–38.8) | 20.4 (15.2–27.7) | 19.5 (13.9–28.4) | 19.9 (17–21.2) | 21.8 (12.3–33.9) | 25.2 (17.1–33.5) | 20.7 (17.1–44.7) | 26 (25.9–33.5)* |