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(A) Strategy to generate the overexpression model which overexpresses the N-terminal region of Magel2 with FLAG-tag. (B) Strategy to generate genome-edited model which carries truncating variant in Magel2. Target sequence for CRISPR/Cas9 (5´-CCACAGGAGCTCCCGGTGCCACA-3´) is located on c.1702-1724, c.1720-1742, c.1810-1832, c.1882-1904 and c.1900-1922 (black triangles).
