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. 2020 Aug 17;15(8):e0231234. doi: 10.1371/journal.pone.0231234

Fig 3. Twenty-week-old obese ZSF1 male rats exhibited cardiovascular dysfunction.

Fig 3

Obese ZSF1 rats show increased blood levels of aldosterone (A), fatty-acid-binding protein 3 (FABP3; B), interleukin-16 (IL-16; C), and ST2 (IL1RL1 gene; D). In obese ZSF1 rats, systemic concentration of NT-proBNP (NPPB gene; E) is lower compared with the lean cohort and osteopontin (OPN; F) level in circulation is not different between the two cohorts. The mRNA expression of FABP3, IL-16, IL1RL1 (ST2 protein), and NPPB (NT-proBNP protein) in left heart was not different between lean and obese ZSF1 groups (G-J), whereas the local SPP1 (OPN protein) mRNA expression in left atria (LA) and left ventricle (LV) (K) was significantly elevated in obese ZSF1 rats. Stars (*) indicate significance (* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001) by unpaired two-tailed t test. n = 8 for lean and n = 8 for obese ZSF1 groups.